Nature Communications (Feb 2017)
Cellular senescence mediates fibrotic pulmonary disease
- Marissa J. Schafer,
- Thomas A. White,
- Koji Iijima,
- Andrew J. Haak,
- Giovanni Ligresti,
- Elizabeth J. Atkinson,
- Ann L. Oberg,
- Jodie Birch,
- Hanna Salmonowicz,
- Yi Zhu,
- Daniel L. Mazula,
- Robert W. Brooks,
- Heike Fuhrmann-Stroissnigg,
- Tamar Pirtskhalava,
- Y. S. Prakash,
- Tamara Tchkonia,
- Paul D. Robbins,
- Marie Christine Aubry,
- João F. Passos,
- James L. Kirkland,
- Daniel J. Tschumperlin,
- Hirohito Kita,
- Nathan K. LeBrasseur
Affiliations
- Marissa J. Schafer
- Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
- Thomas A. White
- Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
- Koji Iijima
- Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine
- Andrew J. Haak
- Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine
- Giovanni Ligresti
- Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine
- Elizabeth J. Atkinson
- Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine
- Ann L. Oberg
- Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine
- Jodie Birch
- Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing
- Hanna Salmonowicz
- Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing
- Yi Zhu
- Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
- Daniel L. Mazula
- Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
- Robert W. Brooks
- Department of Metabolism and Aging, The Scripps Research Institute
- Heike Fuhrmann-Stroissnigg
- Department of Metabolism and Aging, The Scripps Research Institute
- Tamar Pirtskhalava
- Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
- Y. S. Prakash
- Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine
- Tamara Tchkonia
- Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
- Paul D. Robbins
- Department of Metabolism and Aging, The Scripps Research Institute
- Marie Christine Aubry
- Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine
- João F. Passos
- Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing
- James L. Kirkland
- Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
- Daniel J. Tschumperlin
- Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine
- Hirohito Kita
- Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine
- Nathan K. LeBrasseur
- Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
- DOI
- https://doi.org/10.1038/ncomms14532
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fibrosis (IPF), suggesting potential therapy for treatment of human IPF.
