Revista Alergia México (Jul 2015)

Desensitization to darunavir in a pediatric patient

  • Julio César Cambray-Gutiérrez,
  • Patricia López-Pérez,
  • Aurora Alejandra Chávez-García,
  • Leonel Gerardo Del Rivero-Hernández,
  • Nora Hilda Segura-Méndez

DOI
https://doi.org/10.29262/ram.v62i3.112
Journal volume & issue
Vol. 62, no. 3
pp. 251 – 254

Abstract

Read online

Treatment of HIV infection requires the combination of multiple antiretroviral drugs, known as highly active antiretroviral therapy (HAART); however, up to 84% of patients experience adverse drug effects that lead to discontinuation within first months of treatment. Skin manifestations are reported to 22% of patients. The severity of these is variable, such as erythema multiforme, rash, hives and severe skin reactions at less than 2%. Mild rashes, usually transient and self-limiting, while severe reactions require immediately remove the drug involved to prevent progression of the reaction. Only in those cases where the offending drug does not have another alternative and documented the reaction is mediated type I hypersensitivity mechanisms, can be performed desensitization protocol.

Keywords