Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

Michael Koeppen; Jae W. Lee; Seong-Wook Seo; Kelley S. Brodsky; Simone Kreth; Ivana V. Yang; Peter M. Buttrick; Tobias Eckle; Holger K. Eltzschig

doi:10.1038/s41467-018-03105-2

Nature Communications (Feb 2018)

Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

Michael Koeppen,
Jae W. Lee,
Seong-Wook Seo,
Kelley S. Brodsky,
Simone Kreth,
Ivana V. Yang,
Peter M. Buttrick,
Tobias Eckle,
Holger K. Eltzschig

Affiliations

Michael Koeppen: Department of Anaesthesiology and Intensive Care Medicine, Tübingen University Hospital, Eberhard-Karls University Tübingen
Jae W. Lee: Department of Anesthesiology, The University of Texas Health Science Center at Houston, McGovern Medical School
Seong-Wook Seo: Department of Anesthesiology, University of New Mexico School of Medicine
Kelley S. Brodsky: Division of Cardiology, Department of Medicine, University of Colorado School of Medicine
Simone Kreth: Department of Anaesthesiology, Ludwig-Maximilians-University
Ivana V. Yang: Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine
Peter M. Buttrick: Division of Cardiology, Department of Medicine, University of Colorado School of Medicine
Tobias Eckle: Department of Anesthesiology, University of Colorado School of Medicine
Holger K. Eltzschig: Department of Anesthesiology, The University of Texas Health Science Center at Houston, McGovern Medical School

DOI: https://doi.org/10.1038/s41467-018-03105-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Myocardial ischemia–reperfusion injury stabilizes the hypoxia-inducible factor HIF2-alpha. Here, the authors show that HIF2-alpha protects the heart from injury via induction of the epidermal growth factor amphiregulin, and that amphiregulin administration is cardioprotective in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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