A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor

Shoko Kure, MD, PhD; Ryuichi Wada, MD, PhD; Wei-Xia Peng, MD, PhD; Hideaki Ishii, MD, PhD; Taeko Kitamura, MT; Takenori Fujii, MT; Shunta Inai, MD, PhD; Toshitaka Nagao, MD, PhD; Zenya Naito, MD, PhD

doi:10.1016/j.ehpc.2015.10.002

Human Pathology: Case Reports (Sep 2016)

A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor

Shoko Kure, MD, PhD,
Ryuichi Wada, MD, PhD,
Wei-Xia Peng, MD, PhD,
Hideaki Ishii, MD, PhD,
Taeko Kitamura, MT,
Takenori Fujii, MT,
Shunta Inai, MD, PhD,
Toshitaka Nagao, MD, PhD,
Zenya Naito, MD, PhD

Affiliations

Shoko Kure, MD, PhD: Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, Japan
Ryuichi Wada, MD, PhD: Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, Japan
Wei-Xia Peng, MD, PhD: Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, Japan
Hideaki Ishii, MD, PhD: Department of Pathology, Nippon Medical School Hospital, Tokyo, 113-8602, Japan
Taeko Kitamura, MT: Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, Japan
Takenori Fujii, MT: Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, Japan
Shunta Inai, MD, PhD: Department of Otolaryngology, Head and Neck Surgery, Nippon Medical School Hospital, Tokyo, 113-8602, Japan
Toshitaka Nagao, MD, PhD: Department of Anatomic Pathology, Tokyo Medical University, Tokyo, 160-8402, Japan
Zenya Naito, MD, PhD: Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, Japan

DOI: https://doi.org/10.1016/j.ehpc.2015.10.002
Journal volume & issue: Vol. 5, no. C
pp. 18 – 22

Abstract

Read online

We present histological, immunohistochemical and molecular features of oncocytic papillary cystadenocarcinoma, a rare neoplasm of the salivary and parotid glands, in an 82-year-old Japanese man. The resected tumor was solid nodular mass with fibrous capsule. The tumor was composed of papillary proliferation of tall columnar cells with thin vascular cores. The cytoplasm of the tumor cells was granular and eosinophilic. The tumor cells showed clear positive reaction for mitochondria and androgen receptor. GCDFP15 and HER2 were negative. Electron microscopy demonstrated numerous mitochondria in the cytoplasm of the tumor cells. Ki-67 index was 30%. Most of the tumor cells were positive for TP53, and single nucleotide polymorphism was found at codon 151. The invasion into the lymphatic spaces and capsule was noted. Although recurrence and metastasis were not noted at one and a half years after the resection, the patient needs to be followed up under careful observation.

Published in Human Pathology: Case Reports

ISSN: 2214-3300 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: http://www.journals.elsevier.com/human-pathology-case-reports/

About the journal

Abstract

Keywords