Molecules
(Nov 2022)
SNH Amidation of 5-Nitroisoquinoline: Access to Nitro- and Nitroso Derivatives of Amides and Ureas on the Basis of Isoquinoline
Elena K. Avakyan,
Anastasia A. Borovleva,
Diana Yu. Pobedinskaya,
Oleg P. Demidov,
Artem P. Ermolenko,
Alexander N. Larin,
Ivan V. Borovlev
Affiliations
Elena K. Avakyan
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Anastasia A. Borovleva
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Diana Yu. Pobedinskaya
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Oleg P. Demidov
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Artem P. Ermolenko
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Alexander N. Larin
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
Ivan V. Borovlev
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia
DOI
https://doi.org/10.3390/molecules27227862
Journal volume & issue
Vol. 27,
no. 22
Abstract
Read online
For the first time, amides and ureas based on both 5-nitroisoquinoline and 5-nitrosoisoquinoline were obtained by direct nucleophilic substitution of hydrogen in the 5-nitroisoquinoline molecule. In the case of urea and monosubstituted ureas, only 5-nitrosoisoquinoline-6-amine is formed under anhydrous conditions.
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