Nature Communications (Nov 2017)

Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila

  • Gantas Perez-Mockus,
  • Khalil Mazouni,
  • Vanessa Roca,
  • Giulia Corradi,
  • Vito Conte,
  • François Schweisguth

DOI
https://doi.org/10.1038/s41467-017-01482-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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In the Drosophila embryo, increased cortical contractility in ventral cells causes furrow formation and gastrulation. Here, the authors show that contractility is regulated by Neuralized (an E3 ubiquitin ligase) in ventral cells, and that inhibiting this process with Bearded in the ectoderm causes furrow invagination.