Nature Communications (Mar 2020)
A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis
- Corina N. D’Alessandro-Gabazza,
- Tetsu Kobayashi,
- Taro Yasuma,
- Masaaki Toda,
- Heejin Kim,
- Hajime Fujimoto,
- Osamu Hataji,
- Atsuro Takeshita,
- Kota Nishihama,
- Tomohito Okano,
- Yuko Okano,
- Yoichi Nishii,
- Atsushi Tomaru,
- Kentaro Fujiwara,
- Valeria Fridman D’Alessandro,
- Ahmed M. Abdel-Hamid,
- Yudong Ren,
- Gabriel V. Pereira,
- Christy L. Wright,
- Alvaro Hernandez,
- Christopher J. Fields,
- Peter M. Yau,
- Shujie Wang,
- Akira Mizoguchi,
- Masayuki Fukumura,
- Junpei Ohtsuka,
- Tetsuya Nosaka,
- Kensuke Kataoka,
- Yasuhiro Kondoh,
- Jing Wu,
- Hirokazu Kawagishi,
- Yutaka Yano,
- Roderick I. Mackie,
- Isaac Cann,
- Esteban C. Gabazza
Affiliations
- Corina N. D’Alessandro-Gabazza
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Tetsu Kobayashi
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Taro Yasuma
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Masaaki Toda
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Heejin Kim
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Hajime Fujimoto
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Osamu Hataji
- Respiratory Center, Matsusaka Municipal Hospital
- Atsuro Takeshita
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Kota Nishihama
- Department of Diabetes and Endocrinology, Mie University Faculty and Graduate School of Medicine
- Tomohito Okano
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Yuko Okano
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Yoichi Nishii
- Respiratory Center, Matsusaka Municipal Hospital
- Atsushi Tomaru
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Kentaro Fujiwara
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Valeria Fridman D’Alessandro
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Ahmed M. Abdel-Hamid
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Yudong Ren
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Gabriel V. Pereira
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Christy L. Wright
- W.M. Keck Center for Functional and Comparative Genomics, University of Illinois at Urbana–Champaign
- Alvaro Hernandez
- W.M. Keck Center for Functional and Comparative Genomics, University of Illinois at Urbana–Champaign
- Christopher J. Fields
- W.M. Keck Center for Functional and Comparative Genomics, University of Illinois at Urbana–Champaign
- Peter M. Yau
- W.M. Keck Center for Functional and Comparative Genomics, University of Illinois at Urbana–Champaign
- Shujie Wang
- Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine
- Akira Mizoguchi
- Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine
- Masayuki Fukumura
- BioComo Incorporation
- Junpei Ohtsuka
- BioComo Incorporation
- Tetsuya Nosaka
- Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine
- Kensuke Kataoka
- Department of Respiratory Medicine and Allergy, Tosei General Hospital
- Yasuhiro Kondoh
- Department of Respiratory Medicine and Allergy, Tosei General Hospital
- Jing Wu
- Research Institute of Green Science and Technology, Graduate School of Agriculture, Shizuoka University
- Hirokazu Kawagishi
- Research Institute of Green Science and Technology, Graduate School of Agriculture, Shizuoka University
- Yutaka Yano
- Department of Diabetes and Endocrinology, Mie University Faculty and Graduate School of Medicine
- Roderick I. Mackie
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Isaac Cann
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Esteban C. Gabazza
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15344-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Idiopathic pulmonary fibrosis is associated with increased abundance of Staphylococcus and Streptococcus in the lungs. Here, the authors identify a Staphylococcus nepalensis-derived peptide, named corisin, to induce apoptosis of lung epithelial cells and exacerbation of pulmonary fibrosis in mice.
