Removal of Cu(II) using polyphenolic compounds was investigated under batch settings. The influence of extract concentration, initial concentration of metal ion, and contact time on Cu(II) removal was evaluated by Taguchi’s L9 OA; and Larger-the-better analysis and ANOVA was used to find the optimum experimental setup and the impact of various variables. The most significant factor was contact time. Maximum Cu(II) removal of 86.2% experimentally was achieved under the optimal conditions (5 mg/ml; 100 mg/L, and 3 hours) polyphenolic compounds of Phragmites Australis (Cav.) Trin. Steud. root.