Influence of systemic inflammatory reactions on the course of pancreoecrosis

Abstract

Introduction. Acute pancreatitis is a common pathology in abdominal surgery, so the prevalence reaches 238 cases per million populations. It should be noted that pancreatic necrosis develops in 25% of patients with acute pancreatitis, and mortality can reach up to 20%. Purpose of the study. The investigate effect on the pancreatic necrosis course of the systemic inflammatory response. Materials and methods. We examined 96 patients aged from 19 to 78 years. During the course of the disease, a systemic inflammatory response developed in 79% of patients with acute necrotizing pancreatitis. Results. It was found that the lethal cases of acute necrotic pancreatitis occurred only with the development of multiple organ failure with a score of 6 or more on the SOFA scale. The correlation coefficients between the signs, affecting the risk of developing severe multiorgan failure, were calculated. It was proved that in case of a pronounced systemic inflammatory reaction, a patient produces a large amount of free fluid in the abdominal cavity, and is a risk of an early fatal outcome. It should be noted that in the presence of obesity there was a tendency to the risk of developing severe multiorgan failure. Conclusion. In acute necrotizing pancreatitis, the risk of severe multiorgan failure and death is only in patients with a systemic inflammatory reaction (especially in the presence of obesity and the elderly patient), and the degree of risk reliably depends on the severity of signs of an inflammatory response.

Keywords

• acute pancreatitis
• pancreatic necrosis
• systemic inflammatory response syndrome
• multiple organ failure
• septic complications