Osteonecrosis. Part 1. Risk factors and pathogenesis

Abstract

The paper considers different risk factors for osteonecrosis (ON) and some aspects of its pathogenesis: impairments in the differentiation of stromal cells, the vascular provision of intraand extravasal genesis, the quality of proper bone tissue due to generalized or local osteoporosis, intravascular coagulation factors contributing to microthrombogenesis. The basic types of ON are identified.

Keywords

• osteonecrosis
• aseptic necrosis
• avascular necrosis
• osteoblasts
• osteocytes