Correlation between gut microbiota and the development of Graves’ disease: A prospective study
Yuanyuan Deng,
Jiao Wang,
Guijiao Xie,
Guilin Zou,
Shanshan Li,
Jie Zhang,
Wei Cai,
Jixiong Xu
Affiliations
Yuanyuan Deng
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China; Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang 330006, People's Republic of China; Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, People’s Republic of China
Jiao Wang
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China; Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang 330006, People's Republic of China; Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, People’s Republic of China
Guijiao Xie
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China
Guilin Zou
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China; Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang 330006, People's Republic of China; Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, People’s Republic of China
Shanshan Li
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China
Jie Zhang
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China
Wei Cai
Department of Medical Genetics and Cell Biology, Medical College of Nanchang University, Nanchang 330006, People’s Republic of China
Jixiong Xu
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China; Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang 330006, People's Republic of China; Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, People’s Republic of China; Corresponding author
Summary: The association between gut microbiota and development of Graves’ disease (GD) remains unclear. This study aimed to profile the gut microbiota of 65 patients newly diagnosed with GD before and after treatment and 33 physical examination personnel via 16S rRNA sequencing. Significant differences in the gut microbiota composition were observed between the two groups, showing relative bacterial abundances of 1 class, 1 order, 5 families, and 14 genera. After treatment, the abundance of the significantly enriched biota in the GD group decreased considerably, whereas that of the previously decreased biota increased considerably. Further, interleukin-17 levels decreased significantly. The random forest method was used to identify 12 genera that can distinguish patients with GD from healthy controls. Our study revealed that the gut microbiota of patients with GD exhibit unique characteristics compared with that of healthy individuals, which may be related to an imbalance in the immune system and gut microbiota.
