Synergistic Pd/Cu-catalyzed enantioselective Csp2–F bond alkylation of fluoro-1,3-dienes with aldimine esters

Huimin Yu; Qinglong Zhang; Weiwei Zi

doi:10.1038/s41467-022-30152-7

Nature Communications (May 2022)

Synergistic Pd/Cu-catalyzed enantioselective Csp2–F bond alkylation of fluoro-1,3-dienes with aldimine esters

Huimin Yu,
Qinglong Zhang,
Weiwei Zi

Affiliations

Huimin Yu: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Qinglong Zhang: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Weiwei Zi: State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University

DOI: https://doi.org/10.1038/s41467-022-30152-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

Due to high bond dissociation energies of C(sp2)–F bonds, using fluorinated compounds in C(sp2)–C(sp3) cross-coupling is difficult. Here the authors report a protocol for enantioselective C(sp2)–C(sp3) coupling of dienyl fluorides with aldimine esters, enabled by synergistic copper and palladium catalysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal