Przegląd Dermatologiczny (Sep 2016)

Azelaic acid in dermatological treatment – current state of knowledge

  • Radomir Reszke,
  • Jacek Szepietowski

DOI
https://doi.org/10.5114/dr.2016.61785
Journal volume & issue
Vol. 103, no. 4
pp. 337 – 343

Abstract

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Azelaic acid (AZA) is a naturally occurring substance produced by Malassezia furfur which exerts various effects on the skin. Azelaic acid has antibacterial, anti-inflammatory, keratolytic, comedolytic, sebostatic and tyrosinase-inhibiting properties. Topical application of AZA as 20% cream or 15% gel is a well-established therapeutic method in various common dermatoses, mainly acne vulgaris, rosacea and disorders associated with hyperpigmentation. Azelaic acid is used as a component of chemical peels as well. The paper summarizes the most relevant issues concerning AZA application in dermatological treatment based on current knowledge.

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