Nature Communications (Feb 2023)
Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility
- Fengzhe Xu,
- Evan Yi-Wen Yu,
- Xue Cai,
- Liang Yue,
- Li-peng Jing,
- Xinxiu Liang,
- Yuanqing Fu,
- Zelei Miao,
- Min Yang,
- Menglei Shuai,
- Wanglong Gou,
- Congmei Xiao,
- Zhangzhi Xue,
- Yuting Xie,
- Sainan Li,
- Sha Lu,
- Meiqi Shi,
- Xuhong Wang,
- Wensheng Hu,
- Claudia Langenberg,
- Jian Yang,
- Yu-ming Chen,
- Tiannan Guo,
- Ju-Sheng Zheng
Affiliations
- Fengzhe Xu
- School of Life Sciences, Fudan University
- Evan Yi-Wen Yu
- Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Epidemiology & Biostatistics, School of Public Health, Southeast University
- Xue Cai
- School of Life Sciences, Westlake University
- Liang Yue
- School of Life Sciences, Westlake University
- Li-peng Jing
- Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-sen University
- Xinxiu Liang
- School of Life Sciences, Westlake University
- Yuanqing Fu
- School of Life Sciences, Westlake University
- Zelei Miao
- School of Life Sciences, Westlake University
- Min Yang
- School of Life Sciences, Westlake University
- Menglei Shuai
- School of Life Sciences, Westlake University
- Wanglong Gou
- School of Life Sciences, Westlake University
- Congmei Xiao
- School of Life Sciences, Westlake University
- Zhangzhi Xue
- School of Life Sciences, Westlake University
- Yuting Xie
- School of Life Sciences, Westlake University
- Sainan Li
- School of Life Sciences, Westlake University
- Sha Lu
- Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital)
- Meiqi Shi
- Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital)
- Xuhong Wang
- Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital)
- Wensheng Hu
- Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital)
- Claudia Langenberg
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Jian Yang
- School of Life Sciences, Westlake University
- Yu-ming Chen
- Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-sen University
- Tiannan Guo
- School of Life Sciences, Westlake University
- Ju-Sheng Zheng
- School of Life Sciences, Westlake University
- DOI
- https://doi.org/10.1038/s41467-023-36491-3
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
Integrating genetic information with circulating proteomics can help understand mechanisms of disease. Here, the authors conduct genome-wide association analyses of the serum proteome in 2,958 Han Chinese individuals, uncovering proteins which may contribute to ancestry differences in cardiometabolic disease susceptibility.
