Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration

Megha Jhanji; Chintada Nageswara Rao; Jacob C. Massey; Marion C. Hope; Xueyan Zhou; C. Dirk Keene; Tao Ma; Michael D. Wyatt; Jason A. Stewart; Mathew Sajish

doi:10.1038/s41467-022-30785-8

Nature Communications (Jun 2022)

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration

Megha Jhanji,
Chintada Nageswara Rao,
Jacob C. Massey,
Marion C. Hope,
Xueyan Zhou,
C. Dirk Keene,
Tao Ma,
Michael D. Wyatt,
Jason A. Stewart,
Mathew Sajish

Affiliations

Megha Jhanji: Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina
Chintada Nageswara Rao: Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina
Jacob C. Massey: Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina
Marion C. Hope: Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina
Xueyan Zhou: Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine
C. Dirk Keene: Department of Laboratory Medicine and Pathology, University of Washington School of Medicine
Tao Ma: Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine
Michael D. Wyatt: Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina
Jason A. Stewart: Department of Biological Sciences, College of Arts and Sciences, University of South Carolina
Mathew Sajish: Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina

DOI: https://doi.org/10.1038/s41467-022-30785-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Here, the authors show that histone serine-ADP-ribosylation is decreased in Alzheimer’s disease brains and increased tyrosine levels deplete tyrosyl-tRNA synthetase levels and cause neuronal damage. Cis-resveratrol was shown to facilitate histone serine-ADP-ribosylation-dependent DNA repair and provides neuroprotection, while trans-resveratrol induces neurodegeneration in rat cortical neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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