PROSTAGLANDIN Е₂ AS GULL TAPEWORM POTENTiAL iMMUNOMODULATOR

Abstract

This article is devoted to investigation of prostaglandin E2 as potential immunomodulator of gull tapeworm. This parasite has an important epizootic and epidemiological significance in the Lake Baikal and. its basin. Using confocal microscopy, it was revealed that prostaglandin. E2 is produced and. secreted with specialized frontal glands in the organism of gull tapeworm. Using the method of leukocyte culture, the influence of prostaglandin. E2 on immunological reaction of fishes was investigated (by way of example of three-spined stickleback). This immunomodulator decreased the absolute number of leucocytes and. percentage of lymphocytes. Despite of total leukocyte respiratory-burst activity decreasing, respiratory-burst activity per 1 granulocyte remains constant.

Keywords

• prostaglandin e₂
• immunomodulator
• cestodes