Viruses
(Jun 2019)
Clinical Evaluation of QuickNavi<sup>TM</sup>-Ebola in the 2018 Outbreak of Ebola Virus Disease in the Democratic Republic of the Congo
Sheila Makiala,
Daniel Mukadi,
Anja De Weggheleire,
Shino Muramatsu,
Daisuke Kato,
Koichi Inano,
Fumio Gondaira,
Masahiro Kajihara,
Reiko Yoshida,
Katendi Changula,
Aaron Mweene,
Placide Mbala-Kingebeni,
Jean-Jacques Muyembe-Tamfum,
Justin Masumu,
Steve Ahuka,
Ayato Takada
Affiliations
Sheila Makiala
Institut National de Recherche Biomédicale, Avenue de la Démocratie, Kinshasa/Gombe-P.O. Box 1197, Kinshasa I, Democratic Republic of the Congo
Daniel Mukadi
Institut National de Recherche Biomédicale, Avenue de la Démocratie, Kinshasa/Gombe-P.O. Box 1197, Kinshasa I, Democratic Republic of the Congo
Anja De Weggheleire
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
Shino Muramatsu
Denka Seiken Co., Ltd., 1359-1, Kagamida, Kigoshi, Gosen, Niigata 959-1695, Japan
Daisuke Kato
Denka Seiken Co., Ltd., 1359-1, Kagamida, Kigoshi, Gosen, Niigata 959-1695, Japan
Koichi Inano
Denka Seiken Co., Ltd., 1359-1, Kagamida, Kigoshi, Gosen, Niigata 959-1695, Japan
Fumio Gondaira
Denka Seiken Co., Ltd., 1359-1, Kagamida, Kigoshi, Gosen, Niigata 959-1695, Japan
Masahiro Kajihara
Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo 001-0020, Japan
Reiko Yoshida
Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo 001-0020, Japan
Katendi Changula
School of Veterinary Medicine, the University of Zambia, Great East Road Campus, Lusaka, Zambia
Aaron Mweene
School of Veterinary Medicine, the University of Zambia, Great East Road Campus, Lusaka, Zambia
Placide Mbala-Kingebeni
Institut National de Recherche Biomédicale, Avenue de la Démocratie, Kinshasa/Gombe-P.O. Box 1197, Kinshasa I, Democratic Republic of the Congo
Jean-Jacques Muyembe-Tamfum
Institut National de Recherche Biomédicale, Avenue de la Démocratie, Kinshasa/Gombe-P.O. Box 1197, Kinshasa I, Democratic Republic of the Congo
Justin Masumu
Institut National de Recherche Biomédicale, Avenue de la Démocratie, Kinshasa/Gombe-P.O. Box 1197, Kinshasa I, Democratic Republic of the Congo
Steve Ahuka
Institut National de Recherche Biomédicale, Avenue de la Démocratie, Kinshasa/Gombe-P.O. Box 1197, Kinshasa I, Democratic Republic of the Congo
Ayato Takada
Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo 001-0020, Japan
DOI
https://doi.org/10.3390/v11070589
Journal volume & issue
Vol. 11,
no. 7
Abstract
Read online
The recent large outbreaks of Ebola virus disease (EVD) in West Africa and the Democratic Republic of the Congo (DRC) have highlighted the need for rapid diagnostic tests to control this disease. In this study, we clinically evaluated a previously developed immunochromatography-based kit, QuickNaviTM-Ebola. During the 2018 outbreaks in DRC, 928 blood samples from EVD-suspected cases were tested with QuickNaviTM-Ebola and the WHO-approved GeneXpert. The sensitivity and specificity of QuickNaviTM-Ebola, estimated by comparing it to GeneXpert-confirmed cases, were 85% (68/80) and 99.8% (846/848), respectively. These results indicate the practical reliability of QuickNaviTM-Ebola for point-of-care diagnosis of EVD.
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