Pachyonychia congenita: Affecting three generations!

Abstract

Pachyonychia congenita is an autosomal dominantly inherited disease that primarily presents as nail dystrophy and dyskeratosis of skin and mucous membranes. A 32-year-old female presented with thickening of the nails and thickening of both heels. Her father showed pincer nails with periungual thickening of skin and fissures with focal plantar keratoderma. Her two sons had similar nail changes.

Keywords

• Focal palmoplantar keratoderma
• genetic disorder
• nail dystrophy
• pachyonychia congenita