D-serine mitigates cell loss associated with temporal lobe epilepsy

Stephen Beesley; Thomas Sullenberger; Kathryn Crotty; Roshan Ailani; Cameron D’Orio; Kimberly Evans; Emmanuel O. Ogunkunle; Michael G. Roper; Sanjay S. Kumar

doi:10.1038/s41467-020-18757-2

Nature Communications (Oct 2020)

D-serine mitigates cell loss associated with temporal lobe epilepsy

Stephen Beesley,
Thomas Sullenberger,
Kathryn Crotty,
Roshan Ailani,
Cameron D’Orio,
Kimberly Evans,
Emmanuel O. Ogunkunle,
Michael G. Roper,
Sanjay S. Kumar

Affiliations

Stephen Beesley: Department of Biomedical Sciences, College of Medicine & Program in Neuroscience, Florida State University
Thomas Sullenberger: Department of Biomedical Sciences, College of Medicine & Program in Neuroscience, Florida State University
Kathryn Crotty: Department of Biomedical Sciences, College of Medicine & Program in Neuroscience, Florida State University
Roshan Ailani: Department of Biomedical Sciences, College of Medicine & Program in Neuroscience, Florida State University
Cameron D’Orio: Department of Biomedical Sciences, College of Medicine & Program in Neuroscience, Florida State University
Kimberly Evans: Department of Chemistry and Biochemistry, Florida State University
Emmanuel O. Ogunkunle: Department of Chemistry and Biochemistry, Florida State University
Michael G. Roper: Department of Chemistry and Biochemistry, Florida State University
Sanjay S. Kumar: Department of Biomedical Sciences, College of Medicine & Program in Neuroscience, Florida State University

DOI: https://doi.org/10.1038/s41467-020-18757-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Temporal lobe epilepsy (TLE) can be unresponsive to treatment. Here, the authors show that treatment with D-Serine mitigates TLE and acts on neurons and glia, attenuating neuronal loss and reducing astro- and microgliosis in rodents.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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