Successful treatment of rhino-cerebral mucormycosis with dual antifungal therapy and minimal surgical debridement
Lauren Bougioukas,
Cindy D. Noyes,
Katherine Peterson,
Lindsay M. Smith,
Andrew J. Hale
Affiliations
Lauren Bougioukas
North Shore-Long Island Jewish Medical Center, Manhasset, NY, USA
Cindy D. Noyes
University of Vermont Medical Center, Burlington, VT, USA; Larner College of Medicine at the University of Vermont, Burlington, VT, USA
Katherine Peterson
University of Vermont Medical Center, Burlington, VT, USA
Lindsay M. Smith
University of Vermont Medical Center, Burlington, VT, USA; Larner College of Medicine at the University of Vermont, Burlington, VT, USA
Andrew J. Hale
University of Vermont Medical Center, Burlington, VT, USA; Larner College of Medicine at the University of Vermont, Burlington, VT, USA; Correspondence to: University of Vermont Medical Center, Infectious Disease Unit, 111 Colchester Avenue, Mailstop 115 SM2, Burlington, VT 05401, USA.
The authors report the case of a 42-year-old female with history of type I diabetes mellitus and recent episode of diabetic ketoacidosis who presented with symptoms of epistaxis, gastrointestinal upset, hyperglycemia, confusion, and a cough. She was found to have rhino-cerebral mucormycosis with associated multi-focal strokes and a left internal carotid artery pseudoaneurysm. Her infection was successfully treated with dual-antifungal therapy consisting of liposomal amphotericin B and isavuconazole, and required only minimal surgical debridement.
