Nature Communications (Mar 2020)
Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
- Jennifer C. Chan,
- Christopher P. Morgan,
- N. Adrian Leu,
- Amol Shetty,
- Yasmine M. Cisse,
- Bridget M. Nugent,
- Kathleen E. Morrison,
- Eldin Jašarević,
- Weiliang Huang,
- Nickole Kanyuch,
- Ali B. Rodgers,
- Natarajan V. Bhanu,
- Dara S. Berger,
- Benjamin A. Garcia,
- Seth Ament,
- Maureen Kane,
- C. Neill Epperson,
- Tracy L. Bale
Affiliations
- Jennifer C. Chan
- Department of Biomedical Sciences, School of Veterinary Medicine and Perelman School of Medicine, University of Pennsylvania
- Christopher P. Morgan
- Department of Pharmacology and Center for Epigenetic Research in Child Health and Brain Development, University of Maryland School of Medicine
- N. Adrian Leu
- Department of Biomedical Sciences, School of Veterinary Medicine and Perelman School of Medicine, University of Pennsylvania
- Amol Shetty
- Institute for Genome Sciences, University of Maryland School of Medicine
- Yasmine M. Cisse
- Department of Pharmacology and Center for Epigenetic Research in Child Health and Brain Development, University of Maryland School of Medicine
- Bridget M. Nugent
- Department of Pharmacology and Center for Epigenetic Research in Child Health and Brain Development, University of Maryland School of Medicine
- Kathleen E. Morrison
- Department of Pharmacology and Center for Epigenetic Research in Child Health and Brain Development, University of Maryland School of Medicine
- Eldin Jašarević
- Department of Pharmacology and Center for Epigenetic Research in Child Health and Brain Development, University of Maryland School of Medicine
- Weiliang Huang
- Department of Pharmaceutical Science, University of Maryland School of Pharmacy
- Nickole Kanyuch
- Department of Pharmacology and Center for Epigenetic Research in Child Health and Brain Development, University of Maryland School of Medicine
- Ali B. Rodgers
- Department of Biomedical Sciences, School of Veterinary Medicine and Perelman School of Medicine, University of Pennsylvania
- Natarajan V. Bhanu
- Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania
- Dara S. Berger
- Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Perelman School of Medicine, University of Pennsylvania
- Benjamin A. Garcia
- Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania
- Seth Ament
- Institute for Genome Sciences, University of Maryland School of Medicine
- Maureen Kane
- Department of Pharmaceutical Science, University of Maryland School of Pharmacy
- C. Neill Epperson
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Tracy L. Bale
- Department of Pharmacology and Center for Epigenetic Research in Child Health and Brain Development, University of Maryland School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15305-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.
