Symmetric spike timing-dependent plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative networks

Abstract

STDP is dependent on the timing of pre- and post-synaptic activity. Here, the authors describe a symmetric STDP induction rule at CA3-CA3 synapses, which induces LTP over a broad range of paring intervals. Modelling suggests that this STDP rule may enhance storage capacity and pattern completion in the CA3 cell network.