Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation

Sophie Bagur; Julie M. Lefort; Marie M. Lacroix; Gaëtan de Lavilléon; Cyril Herry; Mathilde Chouvaeff; Clara Billand; Hélène Geoffroy; Karim Benchenane

doi:10.1038/s41467-021-22798-6

Nature Communications (May 2021)

Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation

Sophie Bagur,
Julie M. Lefort,
Marie M. Lacroix,
Gaëtan de Lavilléon,
Cyril Herry,
Mathilde Chouvaeff,
Clara Billand,
Hélène Geoffroy,
Karim Benchenane

Affiliations

Sophie Bagur: Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University
Julie M. Lefort: Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University
Marie M. Lacroix: Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University
Gaëtan de Lavilléon: Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University
Cyril Herry: INSERM, Neurocentre Magendie
Mathilde Chouvaeff: Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University
Clara Billand: Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University
Hélène Geoffroy: Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University
Karim Benchenane: Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS, ESPCI Paris, PSL University

DOI: https://doi.org/10.1038/s41467-021-22798-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Combining optogenetics, behavioral modelling and neural population analysis, the authors show in mice that during fear-related freezing the olfactory bulb transmits 4 Hz breathing rhythm to the prefrontal cortex where this oscillation organizes local activity and regulates freezing episode duration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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