Mitochondrial Cristae Architecture and Functions: Lessons from Minimal Model Systems

Abstract

Mitochondria are known as the powerhouse of eukaryotic cells. Energy production occurs in specific dynamic membrane invaginations in the inner mitochondrial membrane called cristae. Although the integrity of these structures is recognized as a key point for proper mitochondrial function, less is known about the mechanisms at the origin of their plasticity and organization, and how they can influence mitochondria function. Here, we review the studies which question the role of lipid membrane composition based mainly on minimal model systems.

Keywords

• cardiolipin
• mitochondria
• cristae
• curvature-based sorting
• cone-shaped lipid asymmetry
• nonbilayer structures