Advances in diagnosis and molecular detection of EBV-positive gastric cancer and gastric cancer with lymphoid stroma

Abstract

Epstein-Barr virus-positive gastric cancer, as well as gastric cancer with lymphoid stroma, are the special pathological subtypes of gastric cancer. The histological morphology, immunological and genetic characteristics between two subtypes are overlapped to some extent, however, they are not identical. Therefore, there were not only the confusion in the diagnosis for pathologists but also perplexity in clinical treatment and following research caused by two subtypes of gastric cancer. In this article, the two cancers and other similar diagnostic terms were introduced and compared in detail. The clinicopathological features, genetic variation, molecular detection, and treatment progress were summarized combined with both current controversies and future directions of research.

Keywords

• |gastric cancer|epstein-barr virus|lymphoid stroma