Frontiers in Cardiovascular Medicine (Nov 2020)

Case Report: A Case Report of Stereotactic Ventricular Arrhythmia Radioablation (STAR) on Large Cardiac Target Volume by Highly Personalized Inter- and Intra-fractional Image Guidance

  • Maria Lucia Narducci,
  • Francesco Cellini,
  • Lorenzo Placidi,
  • Lorenzo Placidi,
  • Luca Boldrini,
  • Luca Boldrini,
  • Francesco Perna,
  • Gianluigi Bencardino,
  • Gaetano Pinnacchio,
  • Roberta Bertolini,
  • Giorgio Cannelli,
  • Vincenzo Frascino,
  • Luca Tagliaferri,
  • Silvia Chiesa,
  • Gian Carlo Mattiucci,
  • Gian Carlo Mattiucci,
  • Mario Balducci,
  • Mario Balducci,
  • Maria Antonietta Gambacorta,
  • Maria Antonietta Gambacorta,
  • Marco Rossi,
  • Luca Indovina,
  • Gemma Pelargonio,
  • Gemma Pelargonio,
  • Vincenzo Valentini,
  • Vincenzo Valentini,
  • Filippo Crea,
  • Filippo Crea

DOI
https://doi.org/10.3389/fcvm.2020.565471
Journal volume & issue
Vol. 7

Abstract

Read online

Introduction: Although catheter ablation is the current gold standard treatment for refractory ventricular arrhythmias, sometimes its efficacy is not optimal and it's associated with high risks of procedural complication and death. Stereotactic arrhythmia radioablation (STAR) is increasingly being adopted for such clinical presentation, considering its efficacy and safety.Case Presentation: We do report our experience managing a case of high volume of left ventricle for refractory ventricular tachycardia in advanced heart failure patient, by delivering a single fraction of STAR through an highly personalization of dose delivery applying repeated inter- and continuous intra-fraction image guidance.Conclusion: According to the literature reports, we recommend considering increasing as much as possible the personalization features and safety technical procedure as long as that is not significantly affecting the STAR duration. Moreover, the duration in itself shouldn't be the main parameter, but balanced into the frame of possibly obtainable outcome improvement. At best of our knowledge, this is the first report applying such specific technology onto this clinical setting. Future studies will clarify these issues.

Keywords