Characteristics of bifidobacteria biological properties in gut microflora disorders in HIV-infected children

Abstract

Aim is to evaluate the biological properties of bifidobacteria in HIV-infected children with different degrees of gut microflora disorders to determine the direction for correction of bifidobacterium in HIV infection.Materials and methods. 58 selected cultures of bifidobacteria from HIV-infected children, 45 children in the comparison group. In bifidobacteria studied adhesion index of microorganisms (IAM), hydrophobicity (H), acid formation, antioxidant activity (AOA), delayed antagonism to opportunistic microorganisms.Results. In HIV-infected children at I degree of gut microflora disorders biological properties of bifidobacteria did not differ from the comparison group (p>0.05). At II degree of gut microflora disorders hydrophobicity of bifidobacteria was 45,75% (33; 58.8), IaM — 2.5 (2,0; 2.9), acid formation 67,30 T (53,0; 97,4), AOA — 0.8 Eaoa (0,6; 1.0). At III degree of gut microflora disorders H — 22,7% (15.8; 46,6), iAm — 2.4 (1,92; 3,69), acid formation — 66,3 T (48,9; 94,9), AOA-0.4 Eaoa (0,3; 0,6). Value biological properties at II and III degrees of gut microflora disorders were lower than in bifidoflora from HIV-negative children (p<0.01).Conclusion. At the I degree of gut microflora disorders in HIV infection it is necessary to correct the quantitative level of bifidobacteria. At II and III degree it is necessary to correct the surface properties, antioxidant and fermentation of carbohydrates activity of bifidobacteria.

Keywords

• bifidobacteria
• hiv infection
• gut microflora
• biological properties