Biomedical Photonics (Mar 2014)
Fluorescence diagnostics and photodynamic therapy: justification of applications and opportunities in oncology
Abstract
This article is dedicated to current research of domestic photosensitizers of different classes carried out by Hertzen Moscow Cancer Research Institute. Results of research in tissue distribution kinetics of Photogem, Photosense, Chlorine e6 based photosensitizers and 5-ALA induced protoporphyrine IX (PPIX) in cancer patients are represented. These results have been used for development of medical techniques in fluorescence diagnostics (FD) and photodynamic therapy (PDT). This article summarizes Hertzen Moscow Cancer Research Institute results of 20 years experience of PD and PDT in patients with different cancer diseases. The most recent data on the efficacy of radical and palliative PDT, anti-relapse intra-operative PDT, prolonged PDT, and PDT combined with chemotherapy are given. Data on sensitivity and specificity of FD in patients with different tumor localizations are represented. The author outlines achievements and challenges of novel FD and PDT methods in clinical practice and defines the main directions of the further FD and PDT development.
