Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Manjeera Gowravaram; Juliane Schwarz; Sana K. Khilji; Henning Urlaub; Sutapa Chakrabarti

doi:10.1038/s41467-019-13080-x

Nature Communications (Nov 2019)

Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Manjeera Gowravaram,
Juliane Schwarz,
Sana K. Khilji,
Henning Urlaub,
Sutapa Chakrabarti

Affiliations

Manjeera Gowravaram: Institute of Chemistry and Biochemistry, Freie Universität Berlin
Juliane Schwarz: Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry
Sana K. Khilji: Institute of Chemistry and Biochemistry, Freie Universität Berlin
Henning Urlaub: Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry
Sutapa Chakrabarti: Institute of Chemistry and Biochemistry, Freie Universität Berlin

DOI: https://doi.org/10.1038/s41467-019-13080-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1. Here the authors report that the nonsense-mediated mRNA decay factor UPF2 mediates the interaction between Stau1 and UPF1 in Staufen-mediated mRNA decay.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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