Research progress of microRNAs suppressing tumorigenesis through Hippo signaling

CHA Na,  HAO Dandan,  LI Tianzhu

doi:10.16352/j.issn.1001-6325.2023.12.1871

Jichu yixue yu linchuang (Dec 2023)

Research progress of microRNAs suppressing tumorigenesis through Hippo signaling

CHA Na, HAO Dandan, LI Tianzhu

Affiliations

CHA Na, HAO Dandan, LI Tianzhu: 1. Department of Oncology, the Affiliated Hospital of Chifeng University, Chifeng 024000;;2. Department of Physiology;;3. Molecular Medicine Research Center, School of Basic Medical Science, Chifeng University, Chifeng 024000, China

DOI: https://doi.org/10.16352/j.issn.1001-6325.2023.12.1871
Journal volume & issue: Vol. 43, no. 12
pp. 1871 – 1875

Abstract

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The aberrant activation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), downstream effectors of the Hippo signaling pathway, has been implicated in hepatocellular carcinoma(HCC). The microRNAs (miRNAs) works as a tumor suppressors that influence the proliferation, migration and apoptosis of tumor cells by modulating Hippo-YAP/TAZ signaling during hepatic tumorigenesis. Exploring the role of miRNAs in regulating Hippo YAP/TAZ pathway in HCC can provide new ideas for the diagnosis and treatment of HCC.

hepatocellular carcinoma|hippo pathway|micrornas|molecular mechanism

Published in Jichu yixue yu linchuang

ISSN: 1001-6325 (Print)
Publisher: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Country of publisher: China
LCC subjects: Medicine
Website: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/1001-6325/home.shtml

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Abstract

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