Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida

Shu Shun Li; Henry Ogbomo; Michael K. Mansour; Richard F. Xiang; Lian Szabo; Fay Munro; Priyanka Mukherjee; Roy A. Mariuzza; Matthias Amrein; Jatin M. Vyas; Stephen M. Robbins; Christopher H. Mody

doi:10.1038/s41467-018-03014-4

Nature Communications (Feb 2018)

Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida

Shu Shun Li,
Henry Ogbomo,
Michael K. Mansour,
Richard F. Xiang,
Lian Szabo,
Fay Munro,
Priyanka Mukherjee,
Roy A. Mariuzza,
Matthias Amrein,
Jatin M. Vyas,
Stephen M. Robbins,
Christopher H. Mody

Affiliations

Shu Shun Li: Department of Microbiology, Immunology and Infectious Diseases, University of Calgary
Henry Ogbomo: Department of Microbiology, Immunology and Infectious Diseases, University of Calgary
Michael K. Mansour: Department of Medicine Division of Infectious Diseases, Massachusetts General Hospital
Richard F. Xiang: Department of Microbiology, Immunology and Infectious Diseases, University of Calgary
Lian Szabo: Department of Medicine, University of Calgary
Fay Munro: Department of Cell Biology and Anatomy, University of Calgary
Priyanka Mukherjee: Department of Cell Biology and Anatomy, University of Calgary
Roy A. Mariuzza: Department of Cell Biology & Molecular Genetics, University of Maryland
Matthias Amrein: Department of Cell Biology and Anatomy, University of Calgary
Jatin M. Vyas: Department of Medicine Division of Infectious Diseases, Massachusetts General Hospital
Stephen M. Robbins: Department of Biochemistry and Molecular Biology, University of Calgary
Christopher H. Mody: Department of Microbiology, Immunology and Infectious Diseases, University of Calgary

DOI: https://doi.org/10.1038/s41467-018-03014-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Natural killer (NK) cells has been show to mediate fungi killing via the activating receptor NKp30, but the fungal target for NKp30 is still unclear. Here the authors show, using atomic force microscopy and live cell imaging, that β-1,3-glucan is expressed by Cryptococcus neoformans and Candida albicans and responsible for NKp30-mediated NK killing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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