Communications Biology (Jul 2021)

Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA

  • Jing Pan,
  • Yao Chen,
  • Qi Zhang,
  • Achia Khatun,
  • Katie Palen,
  • Gang Xin,
  • Li Wang,
  • Chuanjia Yang,
  • Bryon D. Johnson,
  • Charles R. Myers,
  • Shizuko Sei,
  • Robert H. Shoemaker,
  • Ronald A. Lubet,
  • Yian Wang,
  • Weiguo Cui,
  • Ming You

DOI
https://doi.org/10.1038/s42003-021-02381-x
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Pan, Chen, Zhang et al. investigated the anti-cancer efficacy of CA170, a small molecule agonist of VISTA, on mouse lung tumorigenesis. When combined with a MHCII-directed KRAS peptide vaccine, the authors reported that CA170 suppressed lung tumor development by increasing CD8+ T cell and decreasing MDSC and Treg infiltration, while the Kras vaccine induced CD4+ effector T cell expansion