Frontiers in Pharmacology (Oct 2018)

A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway

  • Marina Grimaldi,
  • Marina Grimaldi,
  • Marina Grimaldi,
  • Marina Grimaldi,
  • Abdelhay Boulahtouf,
  • Abdelhay Boulahtouf,
  • Abdelhay Boulahtouf,
  • Abdelhay Boulahtouf,
  • Corinne Prévostel,
  • Corinne Prévostel,
  • Corinne Prévostel,
  • Corinne Prévostel,
  • Alain Thierry,
  • Alain Thierry,
  • Alain Thierry,
  • Alain Thierry,
  • Patrick Balaguer,
  • Patrick Balaguer,
  • Patrick Balaguer,
  • Patrick Balaguer,
  • Philippe Blache,
  • Philippe Blache,
  • Philippe Blache,
  • Philippe Blache

DOI
https://doi.org/10.3389/fphar.2018.01160
Journal volume & issue
Vol. 9

Abstract

Read online

A constitutive activation of the Wnt/β-catenin pathway is an initiating event in colon carcinogenesis. We developed colon cancer cells models that highlight the non-selectivity of previously described inhibitors of the Wnt pathway and we propose our model as a suitable screening system for inhibitors of the pathway.

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