Anthocyanins Formulated with Carboxymethyl Starch for Gastric and Intestinal Delivery
Luiz Bruno De Sousa Sabino,
Francesco Copes,
Solène Saulais,
Edy Sousa De Brito,
Ivanildo José Da Silva Júnior,
Tien Canh Le,
Mircea Alexandru Mateescu,
Diego Mantovani
Affiliations
Luiz Bruno De Sousa Sabino
Department of Chemical Engineering, Federal University of Ceará, Av. Mister Hull, 2977, Campus Universitário do Pici, Fortaleza 60356-000, Ceará, Brazil
Francesco Copes
Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering & CHU de Québec, Regenerative Medicine Division, Laval University, Quebec City, QC G1V 0A6, Canada
Solène Saulais
Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada
Edy Sousa De Brito
Embrapa Agroindústria Tropical, R. Dra Sara Mesquita, 2270, Fortaleza 60511-110, Ceará, Brazil
Ivanildo José Da Silva Júnior
Department of Chemical Engineering, Federal University of Ceará, Av. Mister Hull, 2977, Campus Universitário do Pici, Fortaleza 60356-000, Ceará, Brazil
Tien Canh Le
Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada
Mircea Alexandru Mateescu
Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada
Diego Mantovani
Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering & CHU de Québec, Regenerative Medicine Division, Laval University, Quebec City, QC G1V 0A6, Canada
Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.
