A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia

Shengjie Fan; Yuanzhong Xu; Yungang Lu; Zhiying Jiang; Hongli Li; Jessie C. Morrill; Jing Cai; Qi Wu; Yong Xu; Mingshan Xue; Benjamin R. Arenkiel; Cheng Huang; Qingchun Tong

doi:10.1038/s41467-021-22940-4

Nature Communications (May 2021)

A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia

Shengjie Fan,
Yuanzhong Xu,
Yungang Lu,
Zhiying Jiang,
Hongli Li,
Jessie C. Morrill,
Jing Cai,
Qi Wu,
Yong Xu,
Mingshan Xue,
Benjamin R. Arenkiel,
Cheng Huang,
Qingchun Tong

Affiliations

Shengjie Fan: School of Pharmacy, Shanghai University of Traditional Chinese Medicine
Yuanzhong Xu: Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston
Yungang Lu: Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston
Zhiying Jiang: Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston
Hongli Li: Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston
Jessie C. Morrill: Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston
Jing Cai: Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston
Qi Wu: Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
Yong Xu: Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
Mingshan Xue: Department of Neuroscience and Department of Molecular and Human Genetics, Baylor College of Medicine
Benjamin R. Arenkiel: Department of Molecular and Human Genetics and Department of Neuroscience, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Cheng Huang: School of Pharmacy, Shanghai University of Traditional Chinese Medicine
Qingchun Tong: Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston

DOI: https://doi.org/10.1038/s41467-021-22940-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Leptin can rescue hyperglycemia in type 1 diabetes, but the underlying mechanisms for this effect are not clear. Here, the authors report that leptin action is mediated by inhibition of the heightened activity of arcuate GABA neurons in murine models of type 1 diabetes through restoring nutrient sensing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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