Exploring the Inter- and Intra-Specific Variability of Androctonus Scorpion Venoms

Abstract

Scorpion venom possesses a lethal sting and potential medicinal properties, making it a captivating natural elixir. Our study aimed to unravel the composition of Androctonus scorpionvenoms in Morocco. Using electrospray mass spectrometry and high-performance liquid chromatography (HPLC), we conducted a thorough analysis to gain detailed insights into venom composition. The data unveiled a wide range of molecular weights, influenced by factors such as species, genus, location, age, sex, and diet. Short toxins (2000–4000 Da) predominated in the venoms, effectively blocking K+ channels, while larger molecular weights (>4000 Da) corresponded to long toxins that modulate Na+ channels. Furthermore, we made intriguing discoveries of previously unidentified peptides (<2000 Da). This study provides valuable knowledge, shedding light on the intricate composition of scorpion venoms.

Keywords

• scorpion
• Androctonus
• venom
• peptides
• LC-MS
• peptidic maps