Nature Communications (Jun 2022)
Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET
- Takayoshi Shirasaki,
- Satoshi Yamagoe,
- Tetsuro Shimakami,
- Kazuhisa Murai,
- Ryu Imamura,
- Kiyo-Aki Ishii,
- Hiroaki Takayama,
- Yukako Matsumoto,
- Natsumi Tajima-Shirasaki,
- Naoto Nagata,
- Ryogo Shimizu,
- Souma Yamanaka,
- Atsushi Abe,
- Hitoshi Omura,
- Kazunori Kawaguchi,
- Hikari Okada,
- Taro Yamashita,
- Tomoki Yoshikawa,
- Kazuhiro Takimoto,
- Motoko Taharaguchi,
- Shogo Takatsuka,
- Yoshitsugu Miyazaki,
- Toshikatsu Tamai,
- Yamato Tanabe,
- Makoto Kurachi,
- Yasuhiko Yamamoto,
- Shuichi Kaneko,
- Kunio Matsumoto,
- Toshinari Takamura,
- Masao Honda
Affiliations
- Takayoshi Shirasaki
- Department of Clinical Laboratory Medicine, Kanazawa University Graduate School of Medical Science
- Satoshi Yamagoe
- Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases
- Tetsuro Shimakami
- Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences
- Kazuhisa Murai
- Department of Clinical Laboratory Medicine, Kanazawa University Graduate School of Medical Science
- Ryu Imamura
- Cancer Research Institute, Kanazawa University
- Kiyo-Aki Ishii
- Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
- Hiroaki Takayama
- Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
- Yukako Matsumoto
- Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
- Natsumi Tajima-Shirasaki
- Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
- Naoto Nagata
- Department of Cellular and Molecular Function Analysis, Kanazawa University Graduate School of Medical Science
- Ryogo Shimizu
- Department of Clinical Laboratory Medicine, Kanazawa University Graduate School of Medical Science
- Souma Yamanaka
- Department of Clinical Laboratory Medicine, Kanazawa University Graduate School of Medical Science
- Atsushi Abe
- Department of Clinical Laboratory Medicine, Kanazawa University Graduate School of Medical Science
- Hitoshi Omura
- Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences
- Kazunori Kawaguchi
- Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences
- Hikari Okada
- Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences
- Taro Yamashita
- Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences
- Tomoki Yoshikawa
- Department of Virology I, National Institute of Infectious Diseases
- Kazuhiro Takimoto
- Management Department of Biosafety and Laboratory Animal, National Institute of Infectious Diseases
- Motoko Taharaguchi
- Management Department of Biosafety and Laboratory Animal, National Institute of Infectious Diseases
- Shogo Takatsuka
- Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases
- Yoshitsugu Miyazaki
- Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases
- Toshikatsu Tamai
- Department of Molecular Genetics, Kanazawa University Graduate School of Medical Science
- Yamato Tanabe
- Department of Molecular Genetics, Kanazawa University Graduate School of Medical Science
- Makoto Kurachi
- Department of Molecular Genetics, Kanazawa University Graduate School of Medical Science
- Yasuhiko Yamamoto
- Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science
- Shuichi Kaneko
- Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences
- Kunio Matsumoto
- Cancer Research Institute, Kanazawa University
- Toshinari Takamura
- Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
- Masao Honda
- Department of Clinical Laboratory Medicine, Kanazawa University Graduate School of Medical Science
- DOI
- https://doi.org/10.1038/s41467-022-30879-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The innate antiviral immune response is an important defense against infection. Here, the authors show that leukocyte cell-derived chemotaxin 2 (LECT2) promotes RIG-I-mediated innate immune responses by preventing its degradation, and inhibits lymphocytic choriomeningitis virus replication in the liver.
