A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis

Abstract

B-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is the most common type of ALL, has an excellent prognosis with long-term event-free survival of 90%. The malignancy has several genetic abnormalities that may influence patient prognosis. Rearrangements of the three immunoglobulin genes IGK(2p12), IGH(14q32), and IGL(22q11) are often seen, especially in non-Hodgkin lymphoma (NHL), but recombination of these genes are uncommon. The translocation, t(14;22)(q32;q11) has been reported in only 9 B-cell leukemia/lymphoma cases, but there has been no report about the clinical feature and prognosis of BCP-ALL with t(14;22)(q32;q11). In this paper, we describe the first pediatric case of BCP-ALL with t(14;22)(q32;q11) who presented with a very high white blood cell (WBC) count. He achieved cytogenetic complete remission after induction chemotherapy, and negative minimal residual disease (MRD) at the end of consolidation.

Keywords

• acute lymphoblastic leukemia
• chromosome aberrations
• child
• precursor cell lymphoblastic leukemia-lymphoma