Communications Chemistry (Dec 2020)
Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples
- Masaya Ueno,
- Takuya Tomita,
- Hiroshi Arakawa,
- Takahiro Kakuta,
- Tada-aki Yamagishi,
- Jumpei Terakawa,
- Takiko Daikoku,
- Shin-ichi Horike,
- Sha Si,
- Kenta Kurayoshi,
- Chiaki Ito,
- Atsuko Kasahara,
- Yuko Tadokoro,
- Masahiko Kobayashi,
- Tsutomu Fukuwatari,
- Ikumi Tamai,
- Atsushi Hirao,
- Tomoki Ogoshi
Affiliations
- Masaya Ueno
- Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University
- Takuya Tomita
- Graduate School of Natural Science and Technology, Kanazawa University
- Hiroshi Arakawa
- Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
- Takahiro Kakuta
- WPI Nano Life Science Institute (WPI-Nano LSI), Kanazawa University
- Tada-aki Yamagishi
- Graduate School of Natural Science and Technology, Kanazawa University
- Jumpei Terakawa
- Institute for Experimental Animals, Advanced Science Research Center, Kanazawa University
- Takiko Daikoku
- Institute for Experimental Animals, Advanced Science Research Center, Kanazawa University
- Shin-ichi Horike
- Division of Functional Genomics, Advanced Science Research Center, Kanazawa University
- Sha Si
- Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University
- Kenta Kurayoshi
- Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University
- Chiaki Ito
- Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University
- Atsuko Kasahara
- Institute for Frontier Science Initiative, Kanazawa University
- Yuko Tadokoro
- Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University
- Masahiko Kobayashi
- Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University
- Tsutomu Fukuwatari
- Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture
- Ikumi Tamai
- Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
- Atsushi Hirao
- Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University
- Tomoki Ogoshi
- WPI Nano Life Science Institute (WPI-Nano LSI), Kanazawa University
- DOI
- https://doi.org/10.1038/s42004-020-00430-w
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 1 – 10
Abstract
Quick and accurate measurements of specific metabolites are critical to diagnose certain pathological conditions, but quantification methods for relatively low molecular-weight metabolites are limited. Here, the water-soluble pillar[6]arene is used to specifically and quantitatively detect 1-methylnicotinamide in crude urinary samples.
