Synthesis of pyrimidines using nano-NiZr4 (PO4)6 as a retrievable and robust heterogeneous catalyst

Abstract

Nano-NiZr4 (PO4)6 has been used as an effective and retrievable heterogeneous catalyst for the synthesis of pyrimidines through the reaction of benzaldehydes, guanidinehydrochloride and malononitrile under reflux conditions in ethanol. Experimental simplicity, wide range of products, excellent yields in short reaction times, reusability of the catalyst and low catalyst loading are some of the substantial features of this procedure. The best results were gained in EtOH and we found the convincing results for the synthesis of pyrimidines in the presence of nano-NiZr4 (PO4)6(3 mg) under reflux conditions. The present catalytic method could be extended to a wide diversity of substrates for the synthesis of a variety-oriented library ofpyrimidines.

Keywords

• nanocatalyst
• pyrimidines
• guanidine
• heterogeneous