Exploring the bioactive potential of (2-imino-4-oxo-1,3-thiazolidin-5-yl)acetic acid derivatives: A comprehensive review

Abstract

Thiazolidinone is a scaffold known for its diverse biological activities, drawing the interest of researchers seeking to explore its potential. Numerous libraries of molecules with diverse structures and properties can be created based on this scaffold. We propose the extraction of compounds with a defined central skeleton, resulting from a repeatable methodology of synthesis, to analyze the biological properties of a heterogeneous set of molecules. This review offers a comprehensive overview of recent research, focusing on a homogeneous group of (2-imino-4-oxo-1,3-thiazolidin-5-yl)acetic acid derivatives. It highlights the most promising compounds that have emerged from recent studies, their molecular targets, and the underlying mechanisms contributing to their biological activity.

Keywords

• Thiazolidinone
• Anticancer
• Antimicrobial
• Antiprotozoal
• Anti-inflammatory