Nature Communications (Jan 2023)
Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis
- Jae-Seung Moon,
- Shady Younis,
- Nitya S. Ramadoss,
- Radhika Iyer,
- Khushboo Sheth,
- Orr Sharpe,
- Navin L. Rao,
- Stephane Becart,
- Julie A. Carman,
- Eddie A. James,
- Jane H. Buckner,
- Kevin D. Deane,
- V. Michael Holers,
- Susan M. Goodman,
- Laura T. Donlin,
- Mark M. Davis,
- William H. Robinson
Affiliations
- Jae-Seung Moon
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine
- Shady Younis
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine
- Nitya S. Ramadoss
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine
- Radhika Iyer
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine
- Khushboo Sheth
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine
- Orr Sharpe
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine
- Navin L. Rao
- Immunology Discovery, Janssen Research and Development LLC
- Stephane Becart
- Immunology Discovery, Janssen Research and Development LLC
- Julie A. Carman
- Immunology Discovery, Janssen Research and Development LLC
- Eddie A. James
- Center for Translational Immunology, Benaroya Research Institute
- Jane H. Buckner
- Center for Translational Immunology, Benaroya Research Institute
- Kevin D. Deane
- Division of Rheumatology, University of Colorado Anschutz Medical Campus
- V. Michael Holers
- Division of Rheumatology, University of Colorado Anschutz Medical Campus
- Susan M. Goodman
- Hospital for Special Surgery
- Laura T. Donlin
- Hospital for Special Surgery
- Mark M. Davis
- Institute for Immunity, Transplantation and Infection, Stanford University
- William H. Robinson
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-35264-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing.
