Nature Communications (Mar 2016)

CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

  • Urs Lucas Böhm,
  • Andrew Prendergast,
  • Lydia Djenoune,
  • Sophie Nunes Figueiredo,
  • Johanna Gomez,
  • Caleb Stokes,
  • Sonya Kaiser,
  • Maximilliano Suster,
  • Koichi Kawakami,
  • Marine Charpentier,
  • Jean-Paul Concordet,
  • Jean-Paul Rio,
  • Filippo Del Bene,
  • Claire Wyart

DOI
https://doi.org/10.1038/ncomms10866
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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CSF-contacting neurons are known to project to locomotor CPGs although their relevance to active locomotion is unclear. Here, the authors show that these cells constitute a mechanosensory organ relying on PKD2L1 channels to detect spinal cord curvature and modulate locomotor frequency in freely moving animals.