Nature Communications (Mar 2016)
CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
Abstract
CSF-contacting neurons are known to project to locomotor CPGs although their relevance to active locomotion is unclear. Here, the authors show that these cells constitute a mechanosensory organ relying on PKD2L1 channels to detect spinal cord curvature and modulate locomotor frequency in freely moving animals.