Measurement of platelet p-selectin expression by flow cytometry in patients with acute ischemic stroke

Abstract

Aims: The aim of this study was to asses the platelet activation in the acute phase of ischemic stroke and transient ischemic attack (TIA) by defining p-selectin (CD62) expression by flow cytometry in vivo – without stimulation with agonists. We also studied whether antiplatelet therapy supresses the levels of baseline p-selectin expression and verified if there is a correlation between platelet CD62 expression and the type of ischemic stroke.

Keywords

• flow cytometry
• activated platelets
• ischemic stroke
• p-selectin