Haematologica (Feb 2011)

Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3

  • Tiziano Barbui,
  • Alessandra Carobbio,
  • Guido Finazzi,
  • Alessandro M. Vannucchi,
  • Giovanni Barosi,
  • Elisabetta Antonioli,
  • Paola Guglielmelli,
  • Alessandro Pancrazzi,
  • Silvia Salmoiraghi,
  • Pio Zilio,
  • Cosimo Ottomano,
  • Roberto Marchioli,
  • Ivan Cuccovillo,
  • Barbara Bottazzi,
  • Alberto Mantovani,
  • Alessandro Rambaldi

DOI
https://doi.org/10.3324/haematol.2010.031070
Journal volume & issue
Vol. 96, no. 2

Abstract

Read online

We tested the hypothesis that levels of pentraxin high sensitivity C-reactive protein and pentraxin 3 might be correlated with cardiovascular complications in patients with essential thrombocythemia and polycythemia vera. High sensitivity C-reactive protein and pentraxin 3 were measured in 244 consecutive essential thrombocythemia and polycythemia vera patients in whom, after a median follow up of 5.3 years (range 0–24), 68 cardiovascular events were diagnosed. The highest C-reactive protein tertile was compared with the lowest (>3 vs.