The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

Matteo Villa; Stefania Crotta; Kevin S. Dingwell; Elizabeth M. A. Hirst; Manolis Gialitakis; Helena Ahlfors; James C. Smith; Brigitta Stockinger; Andreas Wack

doi:10.1038/ncomms12652

Nature Communications (Aug 2016)

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

Matteo Villa,
Stefania Crotta,
Kevin S. Dingwell,
Elizabeth M. A. Hirst,
Manolis Gialitakis,
Helena Ahlfors,
James C. Smith,
Brigitta Stockinger,
Andreas Wack

Affiliations

Matteo Villa: Laboratory of AhRimmunity, The Francis Crick Institute, Mill Hill Laboratory
Stefania Crotta: Laboratory of Immunoregulation, The Francis Crick Institute, Mill Hill Laboratory
Kevin S. Dingwell: Laboratory of Developmental Biology, The Francis Crick Institute, Mill Hill Laboratory
Elizabeth M. A. Hirst: EM Technology Platform, The Francis Crick Institute, Mill Hill Laboratory
Manolis Gialitakis: Laboratory of AhRimmunity, The Francis Crick Institute, Mill Hill Laboratory
Helena Ahlfors: Lymphocyte Signalling and Development, The Babraham Institute
James C. Smith: Laboratory of Developmental Biology, The Francis Crick Institute, Mill Hill Laboratory
Brigitta Stockinger: Laboratory of AhRimmunity, The Francis Crick Institute, Mill Hill Laboratory
Andreas Wack: Laboratory of Immunoregulation, The Francis Crick Institute, Mill Hill Laboratory

DOI: https://doi.org/10.1038/ncomms12652
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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