In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy

Shan Lei; Jing Zhang; Nicholas Thomas Blum; Meng Li; Dong-Yang Zhang; Weimin Yin; Feng Zhao; Jing Lin; Peng Huang

doi:10.1038/s41467-022-29082-1

Nature Communications (Mar 2022)

In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy

Shan Lei,
Jing Zhang,
Nicholas Thomas Blum,
Meng Li,
Dong-Yang Zhang,
Weimin Yin,
Feng Zhao,
Jing Lin,
Peng Huang

Affiliations

Shan Lei: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Jing Zhang: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Nicholas Thomas Blum: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Meng Li: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Dong-Yang Zhang: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Weimin Yin: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Feng Zhao: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Jing Lin: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Peng Huang: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center

DOI: https://doi.org/10.1038/s41467-022-29082-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

Photoacoustic imaging can be used to monitor chemical reaction in cells and tissues. Here, the authors develop a Pd based nanozyme conjugated with glucose oxidase that can induce the change of photoacoustic signals during the catalytic cascade process, the system can also be used to treat tumor-bearing mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal