Frontiers in Molecular Neuroscience (Dec 2023)

Emerging diagnostic markers and therapeutic targets in post-stroke hemorrhagic transformation and brain edema

  • Ying Yao,
  • Fei Liu,
  • Zhaowen Gu,
  • Jingyu Wang,
  • Lintao Xu,
  • Yue Yu,
  • Jing Cai,
  • Reng Ren

DOI
https://doi.org/10.3389/fnmol.2023.1286351
Journal volume & issue
Vol. 16

Abstract

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Stroke is a devastating condition that can lead to significant morbidity and mortality. The aftermath of a stroke, particularly hemorrhagic transformation (HT) and brain edema, can significantly impact the prognosis of patients. Early detection and effective management of these complications are crucial for improving outcomes in stroke patients. This review highlights the emerging diagnostic markers and therapeutic targets including claudin, occludin, zonula occluden, s100β, albumin, MMP-9, MMP-2, MMP-12, IL-1β, TNF-α, IL-6, IFN-γ, TGF-β, IL-10, IL-4, IL-13, MCP-1/CCL2, CXCL2, CXCL8, CXCL12, CCL5, CX3CL1, ICAM-1, VCAM-1, P-selectin, E-selectin, PECAM-1/CD31, JAMs, HMGB1, vWF, VEGF, ROS, NAC, and AQP4. The clinical significance and implications of these biomarkers were also discussed.

Keywords