Nature Communications (Jun 2017)
Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis
- Snaevar Sigurdsson,
- Kristjan F. Alexandersson,
- Patrick Sulem,
- Bjarke Feenstra,
- Steinunn Gudmundsdottir,
- Gisli H. Halldorsson,
- Sigurgeir Olafsson,
- Asgeir Sigurdsson,
- Thorunn Rafnar,
- Thorgeir Thorgeirsson,
- Erik Sørensen,
- Andreas Nordholm-Carstensen,
- Jakob Burcharth,
- Jens Andersen,
- Henrik Stig Jørgensen,
- Emma Possfelt-Møller,
- Henrik Ullum,
- Gudmar Thorleifsson,
- Gisli Masson,
- Unnur Thorsteinsdottir,
- Mads Melbye,
- Daniel F. Gudbjartsson,
- Tryggvi Stefansson,
- Ingileif Jonsdottir,
- Kari Stefansson
Affiliations
- Snaevar Sigurdsson
- deCODE Genetics/Amgen Inc.
- Kristjan F. Alexandersson
- deCODE Genetics/Amgen Inc.
- Patrick Sulem
- deCODE Genetics/Amgen Inc.
- Bjarke Feenstra
- Department of Epidemiology Research, Statens Serum Institut
- Steinunn Gudmundsdottir
- deCODE Genetics/Amgen Inc.
- Gisli H. Halldorsson
- deCODE Genetics/Amgen Inc.
- Sigurgeir Olafsson
- deCODE Genetics/Amgen Inc.
- Asgeir Sigurdsson
- deCODE Genetics/Amgen Inc.
- Thorunn Rafnar
- deCODE Genetics/Amgen Inc.
- Thorgeir Thorgeirsson
- deCODE Genetics/Amgen Inc.
- Erik Sørensen
- Department of Clinical Immunology, Copenhagen University Hospital/Rigshospitalet
- Andreas Nordholm-Carstensen
- Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen
- Jakob Burcharth
- Department of Surgery, Herlev Hospital, University of Copenhagen
- Jens Andersen
- Department of Surgery. Gastroenterology, Hvidovre university Hospital
- Henrik Stig Jørgensen
- Department of Surgery, Northern Sealand Hospital
- Emma Possfelt-Møller
- Department of Surgical Gastroenterology, Copenhagen University Hospital/Rigshospitalet
- Henrik Ullum
- Department of Clinical Immunology, Copenhagen University Hospital/Rigshospitalet
- Gudmar Thorleifsson
- deCODE Genetics/Amgen Inc.
- Gisli Masson
- deCODE Genetics/Amgen Inc.
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen Inc.
- Mads Melbye
- Department of Epidemiology Research, Statens Serum Institut
- Daniel F. Gudbjartsson
- deCODE Genetics/Amgen Inc.
- Tryggvi Stefansson
- Department of Surgery, Landspitali, the National University Hospital of Iceland
- Ingileif Jonsdottir
- deCODE Genetics/Amgen Inc.
- Kari Stefansson
- deCODE Genetics/Amgen Inc.
- DOI
- https://doi.org/10.1038/ncomms15789
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 7
Abstract
A hallmark of diverticular disease is pouches in the bowel wall which can become infected and inflamed, causing the more severe diverticulitis. Here, the authors report the first genome-wide association study on these interconnected conditions and identifyARHGAP15, COLQ and FAM155Aas novel risk loci.
