Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19

Yean Kong Yong; Won Fen Wong; Ramachandran Vignesh; Indranil Chattopadhyay; Vijayakumar Velu; Vijayakumar Velu; Hong Yien Tan; Ying Zhang; Marie Larsson; Esaki M. Shankar

doi:10.3389/fimmu.2022.889196

Frontiers in Immunology (Jul 2022)

Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19

Yean Kong Yong,
Won Fen Wong,
Ramachandran Vignesh,
Indranil Chattopadhyay,
Vijayakumar Velu,
Vijayakumar Velu,
Hong Yien Tan,
Ying Zhang,
Marie Larsson,
Esaki M. Shankar

Affiliations

Yean Kong Yong: Laboratory Centre, Xiamen University Malaysia, Sepang, Malaysia
Won Fen Wong: Department of Medical Microbiology, Faculty Medicine, University of Malaya, Kuala Lumpur, Malaysia
Ramachandran Vignesh: Preclinical Department, Royal College of Medicine Perak (UniKL RCMP), Universiti Kuala Lumpur, Ipoh, Malaysia
Indranil Chattopadhyay: Cancer and Microbiome Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India
Vijayakumar Velu: Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States
Vijayakumar Velu: Department of Pathology and Laboratory Medicine, Emory National Primate Research Center, Emory University, Atlanta GA, United States
Hong Yien Tan: School of Traditional Chinese Medicine, Xiamen University Malaysia, Sepang, Malaysia
Ying Zhang: Chemical Engineering, Xiamen University Malaysia, Sepang, Malaysia
Marie Larsson: Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
Esaki M. Shankar: 0Infection Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India

DOI: https://doi.org/10.3389/fimmu.2022.889196
Journal volume & issue: Vol. 13

Abstract

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The dynamics of host-virus interactions, and impairment of the host’s immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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